M3 is a validated, 3-minute, 27-item screening instrument covering depression, anxiety, bipolar disorder, and PTSD in a single check-in — paired with the PEG pain scale. For hospital systems and health plans, M3 provides a standardized way to assess patients at points of care that matter for quality measurement, without adding a new billing relationship or a new EHR integration project.
The program operates within existing CPT codes, including collaborative care and remote patient monitoring, at no incremental cost to the facility, and integrates with leading EHRs including Epic, Cerner, Athena, and eClinicalWorks.
of U.S. adults have Any Mental Illness (AMI) — NIMH
have a Major Depressive Episode — just 35.9% of all diagnosable mental illness
The remaining 64.1% — including anxiety disorders (19.1% prevalence, more than twice that of depression), PTSD, and bipolar disorder — lies entirely outside the reach of depression-only screening. Applying the PHQ-9's 82% sensitivity to that 35.9% ceiling puts its functional detection of AMI at roughly 29%. A validated multi-domain instrument at 83% sensitivity across the full construct detects roughly 83% — a 54-percentage-point gap that no depression-only tool can close, regardless of how well it performs within its own scope. (Modeled estimates from NIMH prevalence data: nimh.nih.gov/health/statistics)
Using a cutoff score of 33, M3 identifies 85% of patients with a confirmed mood or anxiety diagnosis, while only 1 in 10 patients scoring above 33 are diagnosis-free. In a primary care comparison study, M3 demonstrated validity as an efficient tool for screening multiple common psychiatric illnesses — including bipolar disorder and PTSD — in a single assessment, with diagnostic accuracy equal to currently used single-disorder screens. Eighty-three percent of clinicians reviewed the M3 report in 30 seconds or fewer, and 80% found it helpful in reviewing patients' emotional health. See the peer-reviewed validation study: Gaynes et al., Annals of Family Medicine, 2010.
The platform pairs the M3 Checklist with the PEG pain scale, because the two travel together. An NIH-supported study published in the journal PAIN found that adults living with chronic pain were about five times more likely to report symptoms of anxiety or depression than those without chronic pain, yet the two are often evaluated separately. M3 provides separate mental health and pain scores that individuals can share with their care team and repeat over time to monitor changes.
Available on AWS Marketplace, billed per completed assessment straight through your existing AWS bill — no new vendor contract, no separate invoice.
Results are LOINC-coded (panel 71891-6), crosswalked to ICD-10-CM and SNOMED CT, and exportable as HL7 FHIR R4. See Clinical Overview & Security.
Listed on AWS Marketplace as M3MentalHealth.org — A Multi-Dimensional Mood Monitor.